Bioreactor, automation and sampling expertise from Berlin
bbi-biotech develops and supplies configurable bioprocess equipment for customers who need more than a catalogue system – from laboratory bioreactors and xCUBIO automation to patented bioPROBE sampling, retrofit projects and production-oriented solutions.
Premium bioreactors from 250ml to 10,000l
Delivered, installed & serviced worldwide
Unique and patented automated sampling
Retrofit for existing bioreactors
Founded in Berlin in 2009, bbi-biotech combines bioreactor heritage, modern automation, process-oriented engineering and direct technical support for international customers.
A bioprocess equipment company built around real applications
bbi-biotech GmbH is a Berlin-based company specializing in bioreactors, fermenters, automation, sampling and lifecycle support for bioprocess applications.
When the process matters
More than a standard catalogue choice
Customers come to bbi-biotech when vessel configuration, automation, sampling, gas supply, documentation, service access or retrofit requirements cannot be solved by a simple standard catalogue system.
Configured around your application
Technical discussion before system definition
bbi-biotech combines technical discussion, engineering experience and configurable system concepts to help customers define equipment around their actual application – not the other way around.
From lab to production
A technical partner for controlled scale-up
From early laboratory development to pilot-scale systems, production-oriented stainless-steel projects and modernization of existing bioreactors, bbi-biotech supports customers who need a serious technical partner.
We configure bioprocess equipment around the process – not around a fixed catalogue package.
From laboratory systems to production-oriented bioprocess projects
From benchtop systems to retrofit, production systems and automated sampling, these solution areas define what bbi-biotech stands for.
Benchtop Bioreactors
250 ml – 10 L | Glass and autoclavable vessel options
For controlled laboratory-scale cultivation in microbiology and cell culture – early R&D to method development and small-scale process work.
Start here if you need a flexible lab-scale bioreactor with strong configuration freedom.
- Fermentation and cell culture
- Single or twin-vessel configurations
- Double-wall borosilicate glass vessels
- Single-wall glass and stainless-steel vessel options
Parallel Bioreactors
2–24 vessels | Modular process development
For running multiple controlled cultivations side by side – for screening, media development to process comparison and scale-up preparation.
Start here if you need reproducible comparison across several vessels.
- xCUBIO twin for 2 vessels
- xCUBIO multi for up to 24 vessels
- Modular supply-tower architecture
- Same vessel options as benchtop systems
Pilot-Scale Bioreactors
Stainless steel | SIP-capable scale-up systems
For moving from lab development into SIP-capable stainless-steel systems for scale-up, process characterization and pre-production work.
Start here if your process has outgrown laboratory vessels and needs stainless-steel SIP.
- Stainless-steel vessel design
- Automated SIP-capable systems
- CIP depending on project scope
- Typically 2–50 L, sometimes up to 100 L
Production Bioreactors
100 L – 10,000 L+ | Production trains and sterile transfer
For production-scale bioprocesses with stainless-steel sterilizable bioreactors, sterile transfer and complete seed-to-production bioprocessing trains.
Start here if you need production capacity or a complete reactor train.
- Stainless-steel vessel design
- CIP/SIP-capable including transfer lines
- Complete seed-to-production trains
- Optional automated transfer sequences
Retrofit Bioreactors
Existing systems | Modern xCUBIO automation upgrade
For modernizing installed bioreactors with outdated controls – without unnecessary replacement of proven vessels, piping and hardware.
Start here if your existing bioreactor is mechanically valuable but needs modern automation.
- Modern xCUBIO automation
- Reuse of proven vessel and hardware
- New sensors, pumps and extensions
- Integration into one updated control environment
Photobioreactors
Lab to production scale | Phototrophic cultivation systems
For algae and phototrophic processes requiring defined light, specialized reactor concepts and automation beyond standard stirred vessels.
Start here if your process depends on controlled light, phototrophic growth or algae-specific cultivation conditions.
- Lab, pilot and production-scale
- Specialized PBR concepts beyond standard vessels
- Advanced illumination strategies
- xCUBIO automation for phototrophic processes
Bioreactor Sampling
Sterile sampling | Automated dispensing, filtration and storage
For automated, sterile and reproducible sampling from bioreactors – with reliable sample handling for glass, stainless-steel and disposable systems.
Start here if you need defined sampling routines, reduced manual intervention or reproducible sampling
- Automated and reproducible
- For glass, stainless-steel and disposable systems
- Automated dispensing and filtration
- Filtered, cooled or chilled sample storage
Accessories & Spare Parts
Accessories and Wear Parts | Service and Support
For keeping installed bioreactors running, maintained and extendable – with accessories, spare parts, wear parts and technical support from bbi-biotech.
Start here if you need spare parts, accessories, system support or upgrade options for an existing bioreactor setup.
- Manufacturer-independent
- Broad range of accessories and spare parts
- Wear parts and maintenance for running systems
- Support for upgrades and extensions
Why customers talk to bbi-biotech before choosing a bioreactor system
Choosing a bioreactor is rarely only a question of volume. The right system depends on process strategy, vessel concept, sensor setup, gas supply, automation logic, sampling concept, documentation needs and future scale-up path.
bbi-biotech – A legacy bioreactor brand, rebuilt for modern process automation
bbi-biotech GmbH was re-founded in Berlin in 2009, but the roots of the bbi brand reach much further back into one of the most influential chapters of professional bioreactor engineering.
The bbi-biotech brand was already associated with fermenters, bioreactors, automation and controlled bioprocess equipment in the B. Braun Biotech International environment and later continued within Sartorius BBI Systems.
In the 1990s and early 2000s, BBI systems had a very strong presence in professional fermenter and bioreactor installations. For many users, service engineers and process developers, the brand became a familiar reference point for robust bioreactor design, reliable operation, serviceability and long-term system support.
Today, bbi-biotech GmbH carries this legacy forward as an independent company – combining experienced bioreactor leadership with a new generation of automation-focused engineering, xCUBIO control technology, patented bioPROBE sampling, retrofit expertise and configurable bioprocess systems.
For customers, this continuity is practical. It means experience with established system platforms, awareness of how bioreactors are installed and serviced in real facilities, and the ability to translate that knowledge into modern automation, sampling and lifecycle support.
bbi-biotech – timeline
1987
Roots in the B. Braun bioreactor environment
The roots of the bbi-biotech brand go back to the B. Braun Biotech environment, where the bbi / BBI brand became connected with fermenters, bioreactors and controlled bioprocess equipment.
This was not a marginal niche brand. BBI became one of the defining references in professional fermenter and bioreactor technology — with a large installed base that shaped expectations around robust vessels, reliable automation, serviceability and long-term operation.
1990s
Bioreactor experience carried by people
The connection to this legacy is not only a brand story. Two members of today’s bbi-biotech leadership team, Bernd-Ulrich Wilhelm and Norbert Metzler, have worked with bioreactor systems since the B. Braun era in the early 1990s.
Bernd-Ulrich Wilhelm worked with responsibility in sales, product strategy and bioreactor development. Norbert Metzler worked in installation, commissioning and worldwide service of bioreactor systems.
For customers, this means practical experience with real installations, real service situations, real user requirements and the long-term realities of bioprocess equipment.
2000
B. Braun Biotech International becomes part of Sartorius
In 2000, B. Braun Biotech International became part of Sartorius. The BBI brand continued within the Sartorius BBI Systems environment and remained closely connected with fermenters, bioreactors, cell culture systems and automation for laboratory and production applications.
For today’s bbi-biotech, this phase is part of the company’s technical continuity: key people continued to work within an internationally established bioreactor environment, with experience in professional system platforms, customer projects, installation, service and long-term equipment support.
2009
bbi-biotech GmbH re-founded in Berlin
In 2009, bbi-biotech GmbH was re-founded in Berlin by Bernd-Ulrich Wilhelm after the bbi-biotech word/device mark had been officially registered again for the independent company.
The new bbi-biotech was not built as a catalogue supplier. It was built around the idea that serious bioreactor systems should be configurable, serviceable and technically aligned with the customer’s process – supported by automation, sampling, engineering and direct application discussion.
xCUBIO & bioPROBE
Legacy translated into new technology
The re-founded bbi-biotech did not simply continue a familiar brand. It turned established bioreactor understanding into its own technology platform.
With xCUBIO, bbi-biotech developed its own automation environment for configurable bioreactor systems – from laboratory units to pilot systems, in-situ installations, retrofit projects and production-oriented applications.
With patented bioPROBE sampling technology, bbi-biotech added a second core competence: automated sterile sampling, controlled sample transfer and integration into broader process and analytics workflows.
Together, xCUBIO and bioPROBE show what the revived bbi brand stands for today: established bioreactor understanding translated into modern automation, sampling and process-oriented engineering.
Today
Experienced bioreactor thinking, modern automation engineering
Today, bbi-biotech combines experienced bioreactor leadership with a modern automation-focused engineering team.
This combination is especially valuable for customers who need a supplier that understands both sides of the bioreactor world: established systems with technical and economic value, and new configurable platforms built for modern process development, scale-up, production support and automated sampling.
For customers, this means continuity where it matters most: experienced people, modern automation, practical retrofit concepts and support for both new bioreactor projects and existing installations.
bbi-biotech carries forward a strong bioreactor legacy by doing what serious bioprocess projects require today: engineering configurable systems, modernizing valuable installations and developing automation and sampling technologies around real process needs.
Real systems for real bioprocess work
Project examples and real implementations show how bbi-biotech works across new bioreactor systems, retrofit projects, automated sampling and production-oriented bioprocess environments.
Automated sampling for 16 third-party bioreactors in Singapore
In a research environment, four bioPROBE quad systems were integrated with 16 bioreactors to create a more scalable, deeply connected setup.
The project included iceBLOCK as well as extended OPC UA and Lucullus connectivity for more advanced automation and data integration.
Production setup in Germany up to 7000 L for soil health application
A production-oriented project for soil health applications uses xCUBIO automation in vessels up to 7000 L culture volume .
Multiple xCUBIO control units were coordinated to create a consistent automation architecture including units for media preparation.
Cell culture production platform with sterilizable transfer line
An xCUBIO in-situ setup combining a 20 L seed reactor with a 100 L production reactor.
The system was designed around a sterilizable transfer concept between both vessels, with the transfer line integrated into the software functions and CIP, and prepared for separate sterilization.
Retrofit for a large pharmaceutical producer in China
An UD50 and an UD500 bioreactor were upgraded with xCUBIO retrofit automation, including new glucose integration and pressure control.
The project was delivered under difficult lockdown conditions in close cooperation with a local service team.
Planning a bioreactor, sampling or retrofit project?
Start with your process requirements. Tell us what you want to cultivate, which scale you are working at, what kind of system you are considering and which technical constraints matter for your project.
For standard accessories, spare parts and catalogue items, please use the bbi-biotech shop. For general company questions, visit our contact page.
Direct contact to Berlin head office
+49 (0)30 221 800 10
info@bbi-biotech.com
bbi-biotech GmbH
Landsberger Str. 259
12623 Berlin
The brand bbi-biotech is a well-known synonym for innovative fermentors and bioreactors. The bbi-biotech GmbH offers equipment and services for all process applications within biotechnology, pharmaceutical, cosmetic and food industry. bbi-biotech has developed its own portfolio for standard bioreactor vessels as well as for disposable systems of 3rd party suppliers. We succeeded in the development of a modular cultivation system for all different kinds of cells and microorganisms via the joint combination of newest technologies with decades of application experience. The xCUBIO is a bioreactor toolbox with predefined modules, which are selected by your demands and which are combined quickly to your personal solution. Beside the development and production of instruments bbi is offering lectures and technical services. Another central issue of bbi-biotech’s activities is the innovative sampling system bioPROBE for automatic dead-volume-free sampling of fluids to combine cultivation and downstream systems with process analytics.
Our products for the whole biotechnology sector
xCUBIO Fermenters & Bioreactors
Bioreactors for cell culture with glass or steel bioreactors and disposable vessels from different manufacturers. Fermenters for microbial applications with glass, steel and disposable vessels. Photobioreactors or heterotrophic systems for the cultivation of microalgae.
bioPROBE Sampling Systems and Sample Handling Solutions
Aseptic and automatic sampling from all bioreactor types within every bioprocess systems with bioPROBE. Aseptic sample storage, transfer and treatment solutions for the real PAT!
Projects & Plant Engineering
You operate own bioreactors with a certain age? We upgrade your analogue or digital control units to the most recent state-of-the-art to continue your operation on highest technological level. We build your ideas of new bioreactor facilities. We provide basic and detail engineering as well as installation and start-up of all system components.
Company
Founded in 2009 by Mr. Bernd-Ulrich Wilhelm, a pioneer in biotechnological engineering, bbi-biotech GmbH is based in Berlin, Germany. We are at the forefront of developing, manufacturing, and distributing advanced fermenter systems, bioreactors, and our revolutionary automatic sampling technology, bioPROBE.
Innovating Bioprocessing
Our proprietary bioPROBE technology automates bioreactor sampling, setting a new industry standard where traditionally 90% of such tasks are still done manually. This innovation not only enhances reliability but also ensures uncompromised sterility without the complications seen in other automated methods.
Global Impact and Recognition
The bbi-biotech logo is a mark of quality and innovation recognized on thousands of bioreactors across the globe, a testament to our heritage and the trust we have cultivated in the market. Our xCUBIO line offers a comprehensive range of bioreactor solutions, from 250ml autoclavable glass bioreactors to 10,000l in-situ sterilizable units, alongside versatile controllers designed for Single-Use vessels, demonstrating our broad expertise and robust market presence.
Philosophies Driving Excellence
We operate under strict principles to ensure the highest quality and client satisfaction:
- No compromises when it comes to sterility!
- Innovation and customization sets us apart from the competition!
- We adapt our products to the process of the customer. We never make the customer adapt his process to our products!
A Trusted Partner
Supported by over 300 specialist suppliers and a network of more than 10,000 industry contacts developed over three decades, bbi-biotech is deeply rooted in the biotechnology sector.
Discover how our innovative solutions are making a difference in the bioprocessing industry and learn more about our cutting-edge technologies on our website.
Management
Bernd-Ulrich Wilhelm, CEO
E-Mail: info@bbi-biotech.com
Bernd-Ulrich Wilhelm, founder and CEO of bbi-biotech GmbH, stands as a leading authority in the bioprocess industry. His distinguished career began at Humboldt University in Berlin, where he gained a formidable foundation in mathematics and physics, propelling him into the world of biotechnology research and business development.
Early in his career, Bernd-Ulrich honed his skills at an industrial biotechnology research institute, focusing on data analysis and the optimization of fermentation processes. His transition to B. Braun Diessel Biotech GmbH (later B.Braun Biotech International GmbH) marked a pivotal turn towards commercial roles. There, he led sales and distribution efforts across various European regions, enhancing client relations and accelerating business growth through his expert management.
His professional journey continued to evolve at Sartorius BBI Systems GmbH, where he assumed the role of Head of Marketing, R&D, and Sales for standard fermentation and bioreactor equipment. In this capacity, Wilhelm’s strategic insight and leadership were key to developing and marketing successful biotechnological solutions.
As the CEO of bbi-biotech GmbH, Bernd-Ulrich Wilhelm applies his extensive experience in research, sales, and marketing to drive the company’s success in offering innovative, high-quality solutions to the bioprocess industry. Under his stewardship, bbi-biotech has cultivated a reputation for excellence and reliability, positioning itself as a trusted partner in the global market for state-of-the-art bioprocess equipment and services.
Ronnie Wilhelm, Head of Business Development and Sales
With a strong foundation in information and communication technologies from the Technical University of Berlin, Ronnie Wilhelm has been a pivotal figure at bbi-biotech GmbH.
His journey with the company began in the realm of innovation, where he led the development of the automated and internationally patented sampling system, bioPROBE, affirming bbi-biotech’s dedication to cutting-edge bioprocess technology.
Now, as Head of Business Development and Sales, Ronnie not only continues to lead the software team with expertise but also spearheads the expansion of bbi-biotech’s sales strategy. His multifaceted role involves nurturing the company’s growth while maintaining the integrity of its technological advances, particularly in extending the reach of bbi-biotech’s distribution network throughout Asia.
Ronnie’s comprehensive approach to blending development and sales ensures that bbi-biotech’s offerings are not just technologically superior but also globally accessible and supported.
Norbert Metzler, Head of Process Engineering
Norbert Metzler is a seasoned expert in biotechnology and chemical engineering, with over three decades of experience in the bioprocess industry.
Beginning his career in 1989 at FZB Biotechnik GmbH in Berlin, he quickly rose to Head of Production, significantly contributing to the company’s growth and simultaneously expanding his expertise as a service technician with ARA-Service Berlin.
In 1999, he joined B Braun Biotech International as a field service engineer, where he continued to excel through the company’s transition to Sartorius BBI Systems GmbH. Since 2009, Norbert has been at the forefront of bbi-biotech GmbH as the Head of Process Engineering. He oversees the design of fermentation systems and manages essential services including start-up, maintenance, and user training, ensuring top-quality service in bioprocess plant operations.
His involvement in the installation and planning of over 6,000 bioreactors worldwide showcases his vast experience and dedication to excellence, making him a pivotal asset to bbi-biotech GmbH and the bioprocess industry.
Conferences & Exhibitions
54. China International Pharmaceutical Machinery Exposition 2017, 6.-8.November, Changsha International Convention and Exhibition Center
We exhibit: xCUBIO multi, bioPROBE quad, multiSAM
bbi-biotech goes China. For the first time ever we present a part of our portfolio in China – at the 54th CIPM – China’s largest and leading show of pharmaceutical industry. With 26 years of contributing to the Chinese pharmaceutical industry, CIPM has firmly established itself as the industry’s must-attend show in China. Visit us at booth E1-30-6. Discuss with our experts from Germany and China the feasibility of your ideas and find out what bbi-biotech can do to optimize your biotech lab.
Medica 2017, 13.-16.November, Messe Düsseldorf
We exhibit: bioPROBE, multiSAM
We are delighted to welcome you at Medica 2017 from 13.-16. November at Messe Düsseldorf at the Berlin-Brandenburg booth – Booth F42 in Hall 15. Let our experts show and explain the advantages of the automated sterile sampling device bioPROBE and the flexibility of the highly-awarded autsampler multiSAM
Our staff aditionally visits the leading trade fairs of biotechnology, analytics and bio process engineering. Please contact us if you attend an event and like to meet us. We like to arrange independent meetings on site as well.
Exhibitions & Conferences – Retrospectives
Exhibitions & Conferences 2017
10.Bundesalgenstammtisch 2017
bbi-biotech presented at 10. Bundesalgenstammtisch in the Ständehaus in Merseburg the new xCUBIO phar spirale – the smallest tubular photobioreactor in the world – now with 4 or 8 separately adjustable LED wave lengths. Special highlight – the customer himself can determine, with which wave lengths his xCUBIO phar photobioreactor will be equipped.
Exhibitions & Conferences 2016
Visit us at Analytica 2016, 10.-13.Mai, Messe Munich – We show xCUBIO multi, xCUBIO in-situ, xCUBIO phar, bioPROBE and multiSAM!
We look forward to welcome you from Mai 10th to 13th on the Analytica 2016 at the Munich Fairground, Germany, in Hall A3, booth 325. Discover the novel bioreactor concept xCUBIO multi with its central operating terminal and let yourself get introduced into our unrivalled sampling system bioPROBE, connected to the novel Autosampler multiSAM. Feel free to discuss your ideas with our experts and check the opportunities of our biotech products.
Exhibitions & Conferences 2014
Wir stellen aus: Probenahme bioPROBE und Probenhandlingsystem orbitSAM: 11.09. -12.09.2014 in der Musik- und Kongresshalle, Lübeck
Die Lübecker Fraunhofer Einrichtung Marine Biotechnologie lädt mit Unterstützung der Norgenta Norddeutsche Life Science Agentur GmbH zum 5. Kongress für Industrielle Zelltechnik am 11.09. und 12.09.2014 in der Musik- und Kongresshalle Lübeck ein. Dieses Jahr werden im Fokus des Kongresses Möglichkeiten für die Massenproduktion von Zellen in Bioreaktoren stehen, aber auch die Nutzung von Zellen und Zellinhaltsstoffen (Rohstoff Zelle) als eines der modernen nachhaltigen Produktionsverfahren.
Auf dem Stand von Baacklab stellen wir unseren Beitrag zum Gelingen der industriellen Zellkultur vor. Mit bioPROBE und der patentierten Sondentechnologie können vollautomatisch, totvolumenfrei und 100% steril Proben aus Fermentern und Bioreaktoren jeden Types genommen werden, während das Handlingsystem orbitSAM die Probenlagerung für die weitere Analytik übernimmt. Besuchen Sie uns auf dem Stand von Baacklab und lassen Sie sich die Systeme vorführen!
Our automatic sampling system at the BioTech 2014: 4. & 5. September in Zurich, Switzerland
CEO Bernd-Ulrich Wilhelm presents our automatic sterile sampling system bioPROBE with a lecture and an additional workshop at this year’s BioTech Chemical Sensors Forum on Bioprocess Analytics and Sensor Technology. The Forum happens on September 4th and 5th at the Campus Grüenetal of the Zurich University of Applied Sciences in Wädenswil, Switzerland.
New prospects for process control
Mr. Wilhelm presents our sampling system bioPROBE within his lecture, titled “New prospects for process control using universal sampling systems”, and demonstrates the unique opportunities of this innovative system. The bioPROBE allows sterile and automated sampling of even smallest samples from bioreactors and fermenters of any type without the presence of any operating staff. Sampling processes are possible even on weekend, during holiday or during overnight cultivations without additional security issues or increased expenditure on personnel.
In addition, Mr. Wilhelm will present bioPROBE‘s different opportunities on sampling handling. Next to the central process of simple sampling into cutomer’s collecting vessels from 5 up to 50 ml, bioPROBE can be combined with our sample cooling device coolSAM for storage and fixation of the sample. Another opportunity is the orbitSAM fraction collector for increased sample numbers. Even atline-analyses can be realized with the complete control technology of the bioPROBE, e.g. the sample transfer to automatic cytometers like the vi-cell from Beckman Coulter.
We look forward to your visit at this conference and your interesting questions. Please find more information on program, venue and registration on the conference’s website www.biotech2014.ch.
Update from the happening
Exhibitions & Conferences 2012
Analytica
Our distributor Armin Baack presented our sampling system bioPROBE MK1 at his booth.
Exhibition & Conferences 2011
Biotechnica
Our distributor Armin Baack presented our sampling system bioPROBE MK1 at his booth.
Exhibition & Conferences 2010
Analytica
Presentation of our sampling system bioPROBE MK1 and cooling sample collector coolSAM at the pavilion Germany of the Bundesministeriums für Wirtschaft „made in Germany“.
Dechema Vortrags- und Diskussionstagung „Bioprozessorientiertes Anlagendesign“
bbi-biotech articlePoster presentation: „Universales, vollautomatisches Probenahmesystem für Bioreaktoren“
Exhibition & Conferences 2009
Achema
Presentation of a prototype of the sampling system
Biotechnica
Presentation of sampling device and possible connections to analytical devices and applications
Technische Universität Berlin Symposium
“PAT – new possibilities by universal sampling devices”
Partners
Distributors
ARA-Service Detlef Mohnke
The main business of ARA-Service is the technical service of fermenters and autoclaves. In addition to the sale of xCUBIO bioreactors, ARA-Service supports us with technical advice and procurement of spare parts.
F & E – Partner
Abitep GmbH Die Abitep GmbH ist Partner für Applikationsuntersuchungen bei mikrobiellen Prozessen. Link: www.abitep.de
B&R
B&R is our reliable partner for the delivery of automation hardware.
Link: www.br-automation.com
Cercell
We cooperate with the Danish company CerCell in the development of novel disposable cultivation systems.
Link: www.cercell.com
Gemtec
Gemtec is a reliable partner for the development of serial components. A cooperation for the use of Siemens automation systems exists for the manufacture of large-scale systems.
Link: www.gemtec.eu
IGV Biotech
IGV Biotech provided photobioreactors to the world market for more than thirty years and is leading in the microalgae product development. IGV Biotech is a reliable partner for the development of our high-end photobioreactor series.
Link: www.igv-gmbh.de
InVivo Biotech Services GmbH
Invivo GmbH tests bbi-developments concerning cell culture and supports our customers in training and application instructions.
Link: www.invivo.de
Hochschulen
TH Wildau
bbi-biotech and TH Wildau cooperate in various projects for developing bioreactor components.
Mitgliedschaften
Dechema
Link: www.dechema.de
Förder- & Entwicklungsprojekte
In addition to our own development of new systems, bbi-biotech has joined research and development projects with other companies and institutes. Our staff supplies well-funded technical know-how for technological solutions in biotechnological processes. Innovative ideas earn a feasible approach and promising project partnerships.
Newsletter
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