
Aseptic und automated sampling for bioreactors
bbi-biotech supplies automatic sampling systems for all applications within biotechnology, pharmaceutical, food, cosmetics and chemical industry.
Automated – Sterile – Dead volume free
Sampling systems by bbi-biotech connect all offline-analytical instruments to every bioreactor type. Bioreactor vessels from stainless steel, glass or disposable materials like bags can be equipped directly or in a bypass.

Key features of the bioreactor sampling system bioPROBE
Automated and continuous Sampling – bioPROBE delivers sterile samples at the push of a button or fully automated. 24 hours a day. Every Day.Learn more about the automation possibilities of bioPROBE
Sterile samples at the push of a button
bioPROBE gives you the unique possibility to draw sterile samples anytime you want – without any further preparation; simply by pushing a button or clicking a mouse.
Even when bioPROBE is processing a pre-configured sampling plan, you always have the opportunity to take an additional, unscheduled sample.
Automated sterile samples
The real strength of bioPROBE is the processing of pre-scheduled sampling plans.
The web interface of bioPROBE, that is specifically tailored to fit the requirements of biotechnological processes, helps to easily create sampling plans by defining equidistant and custom sample steps.
Once configured the execution of the sampling plan will be completely automatic. 24 hours a day. Every day.

Sterility by Design – bioPROBE operates due to the unique and patented sampling technology sterile and aseptic by design. No clogging filters! No biofilms!
Learn more about the sterility by design concept of bioPROBE
Idle phase: A stainless steel or PEEK seal closes under pressure like a check valve the fermenter. The pressure is constantly monitored and maintained by an elaborate leakage management system.
Sampling phase: The seal is opened. Medium, embedded in a sterile gas cushion, is transported in the desired quantity from the bioreactor. Like in a S4 laboratory negative pressure ensures that medium can only flow from the bioreactor to the outside. The path towards the bioreactor remains blocked, the sterility of the culture is guaranteed at all times.

Dead volume free – bioPROBE is suitable for even the smallest culture vessels. Reduce the loss of valuable product due to sampling to an absolute minimum.
Learn more about dead volume free sampling
bioPROBE samples from the bioreactor only the volume that is necessary for the analysis or quality control. bioPROBE allows smallest sample volumes from 0.5 ml, with no volume wasted in tubes or other parts of the sampling system.
By transporting the sample in a cushion of sterile gas, the tubing system is cleaned automatically. The entire volume is available for the analysis, nothing is discarded.

Learn more about the time reductions with bioPROBE
Until now sterile sampling from a bioreactor was time- and labor-intensive. bioPROBE reduces the costs for trainings and lab staff dramatically.
Manual Sampling | Sampling with bioPROBE | |
---|---|---|
Cleaning of equipment | 7 min | 0 min |
Assembly of Equipment | 3 min | 0 min |
Sampling | 2 min | 0 min |
Disassembly of Equipment | 4 min | 0 min |
samples/year | 1800 | 1800 |
man hours/year | 480 | 0 |
man weeks/year | 12 | 0 |
*comparison betweeen time needed for manual sampling and sampling with bioPROBE (based on average figures) |
- bioPROBE reduces the expenses for laboratory staff
- bioPROBE reduces the expenses for laboratory training
- bioPROBE reduces the expenses for night and weekend pay

Amortization with 1500 samples – Manual sampling is time consuming and one of the most expensive activities in modern biotech laboratories
Learn more about the amortization of bioPROBE

Learn more about the possibilities of more and more precise samples with bioPROBE
More samples mean
- better and more relevant results
- quality improvement and better process control
- better reproducibility and comparability of data
- improved process safety and reliability

Easiest operability – bioPROBE is configurable with every PC or smart phone via a standard browser (e.g. Chrome, IE, Firefox). Its operation can be learned in less than 5 minutes.
Learn more about the unique user interface of bioPROBE

bioPROBE uses modern web technologies to provide the best user experience possible and utmost convenience.
Configure and check on bioPROBE via PC, tablet or a smart phone from your office, your lunch break or even from home.
Sterile samples for everybody. – bioPROBE reduces the need for highly qualified lab personnel to draw sterile samples from a bioreactor | fermentor. Operating bioPROBE is easier than making coffee.

bioPROBE HMI on a macbook
Gain flexibility – Don’t become a slave of your sampling plan. With bioPROBE you decide when to be in the lab.
bioPROBE versions
bioPROBE is available in various versions.
bioPROBE solutions
bbi-biotech has already developped various off-the-shelf sampling solutions