Configurable bioreactor systems, retrofit solutions and automated sampling for demanding biotech processes
From R&D to pilot and production, bbi-biotech provides configurable bioreactor systems, retrofit solutions, automated sampling, service and spare parts for complex applications in biotechnology, pharma, food and related process industries.
Premium bioreactors from 250ml to 10,000l
Delivered, installed & serviced worldwide
Unique and patented automated sampling
Retrofit for existing bioreactors
Our flagship solutions for demanding bioprocesses
From benchtop systems to retrofit and automated sampling, these solution areas define what bbi-biotech stands for.
Benchtop Bioreactors
250 ml – 10 L | Glass and autoclavable vessel options
For controlled laboratory-scale cultivation in microbiology and cell culture – early R&D to method development and small-scale process work.
Start here if you need a flexible lab-scale bioreactor with strong configuration freedom.
- Fermentation and cell culture
- Single or twin-vessel configurations
- Double-wall borosilicate glass vessels
- Single-wall glass and stainless-steel vessel options
Parallel Bioreactors
2–24 vessels | Modular process development
For running multiple controlled cultivations side by side – for screening, media development to process comparison and scale-up preparation.
Start here if you need reproducible comparison across several vessels.
- xCUBIO twin for 2 vessels
- xCUBIO multi for up to 24 vessels
- Modular supply-tower architecture
- Same vessel options as benchtop systems
Pilot-Scale Bioreactors
Stainless steel | SIP-capable scale-up systems
For moving from lab development into SIP-capable stainless-steel systems for scale-up, process characterization and pre-production work.
Start here if your process has outgrown laboratory vessels and needs stainless-steel SIP.
- Stainless-steel vessel design
- Automated SIP-capable systems
- CIP depending on project scope
- Typically 2–50 L, sometimes up to 100 L
Production Bioreactors
100 L – 10,000 L+ | Production trains and sterile transfer
For production-scale bioprocesses with stainless-steel sterilizable bioreactors, sterile transfer and complete seed-to-production bioprocessing trains.
Start here if you need production capacity or a complete reactor train.
- Stainless-steel vessel design
- CIP/SIP-capable including transfer lines
- Complete seed-to-production trains
- Optional automated transfer sequences
Retrofit Bioreactors
Existing systems | Modern xCUBIO automation upgrade
For modernizing installed bioreactors with outdated controls – without unnecessary replacement of proven vessels, piping and hardware.
Start here if your existing bioreactor is mechanically valuable but needs modern automation.
- Modern xCUBIO automation
- Reuse of proven vessel and hardware
- New sensors, pumps and extensions
- Integration into one updated control environment
Photobioreactors
Lab to production scale | Phototrophic cultivation systems
For algae and phototrophic processes requiring defined light, specialized reactor concepts and automation beyond standard stirred vessels.
Start here if your process depends on controlled light, phototrophic growth or algae-specific cultivation conditions.
- Lab, pilot and production-scale
- Specialized PBR concepts beyond standard vessels
- Advanced illumination strategies
- xCUBIO automation for phototrophic processes
Bioreactor Sampling
Sterile sampling | Automated dispensing, filtration and storage
For automated, sterile and reproducible sampling from bioreactors – with reliable sample handling for glass, stainless-steel and disposable systems.
Start here if you need defined sampling routines, reduced manual intervention or reproducible sampling
- Automated and reproducible
- For glass, stainless-steel and disposable systems
- Automated dispensing and filtration
- Filtered, cooled or chilled sample storage
Accessories & Spare Parts
Accessories and Wear Parts | Service and Support
For keeping installed bioreactors running, maintained and extendable – with accessories, spare parts, wear parts and technical support from bbi-biotech.
Start here if you need spare parts, accessories, system support or upgrade options for an existing bioreactor setup.
- Manufacturer-independent
- Broad range of accessories and spare parts
- Wear parts and maintenance for running systems
- Support for upgrades and extensions
Why bbi-biotech
For many teams, standard equipment is not enough. That is where bbi-biotech excels.
We adapt the system to the process – not the process to the system
When standard platforms do not fit the real process, bbi-biotech offers more freedom in system design, vessel selection, interfaces and automation. The result is a solution built around the application, not around the limitations of a fixed product package.
One automation from benchtop to scale-up
Instead of different control concepts for different sizes, xCUBIO provides one shared automation foundation across the portfolio. This improves transferability, reduces friction in operation and training, and makes scale-up more consistent.
Retrofit expertise for existing installations
Valuable bioreactors do not have to be replaced just because existing automation has become outdated or unreliable. bbi-biotech modernizes installed systems with technical depth, practical judgment and real respect for the value of existing equipment.
Automated sterile sampling as a system capability
With bioPROBE and matching autosamplers, bbi-biotech offers automated sterile sampling for bioprocess environments where reproducibility, reduced manual intervention and reliable sample handling matter.
No compromises when it comes to sterility
For many applications, sterility is not just one requirement among many, but the condition everything else depends on. bbi-biotech designs systems, assemblies and process solutions with a clear focus on reliable sterile operation.
Long-term reliable bioreactor service & support
Service, spare parts, retrofit and new systems work together at bbi-biotech. The result is support that does not end with delivery, but remains relevant throughout operation, expansion and technical development.
Where technical credibility becomes tangible
References, project examples and real implementations show how broadly, how practically and how application-close bbi-biotech operates across both new and existing bioprocess environments.
Automated sampling for 16 third-party bioreactors in Singapore
In a research environment, four bioPROBE quad systems were integrated with 16 bioreactors to create a more scalable, deeply connected setup.
The project included iceBLOCK as well as extended OPC UA and Lucullus connectivity for more advanced automation and data integration.
Production setup in Germany up to 7000 L for soil health application
A production-oriented project for soil health applications uses xCUBIO automation in vessels up to 7000 L culture volume .
Multiple xCUBIO control units were coordinated to create a consistent automation architecture including units for media preparation.
Cell culture production platform with sterilizable transfer line
An xCUBIO in-situ setup combining a 20 L seed reactor with a 100 L production reactor.
The system was designed around a sterilizable transfer concept between both vessels, with the transfer line integrated into the software functions and CIP, and prepared for separate sterilization.
Parallel 5 L bioreactor platform with dissolved CO₂ sensors
A customized xCUBIO twin/multi setup for parallel 5 L reactors combined a multi controller architecture with dedicated CO₂ process integration.
The xCUBIO bioreactors were prepared for Mettler-Toledo dissolved CO₂ probes and supported by CO₂ mass-flow control and pCO₂-oriented automation functions.
Retrofit for a large pharmaceutical producer in China
An UD50 and an UD500 bioreactor were upgraded with xCUBIO retrofit automation, including new glucose integration and pressure control.
The project was delivered under difficult lockdown conditions in close cooperation with a local service team.
Retrofit for German university of 300l B.Braun reactor
An xCUBIO retrofit project for a 300 L installed fermenter, designed to modernize automation while preserving key existing hardware.
The setup retained the existing vessel, temperature unit, agitator drive, pump functions and sensor interfaces.
Phototrophic platform in New Zealand with later expansion
An xCUBIO phar multi bubble first supplied with 8 × 1 L vessels and later expanded to 16 bubble-columns with 16 dedicated illumination units.
The system was configured with tailored wavelengths and advanced automation features for phototrophic process development.
Steam-sterilizable photobioreactor system at a US university
An xCUBIO phar in-situ system with 125 L cultivation volume, optionally expandable to 200 L with a second cultivation unit.
Designed for steam sterilization, equipped with fluorescent-tube illumination, and featuring electric heating for standard operation.
Tell us what you need
Whether you need a quote, a technical discussion, a retrofit assessment or service support, we will route your enquiry to the right context.
I want a meeting
For technical requirements, process fit and configurations.
I need a quote
For new systems, retrofits or defined purchasing needs.
I need a spare part
For running systems, service cases or upgrades.
Direct contact to Berlin head office
+49 (0)30 221 800 10
info@bbi-biotech.com
bbi-biotech GmbH
Landsberger Str. 259
12623 Berlin