SIP/CIP-Technology for High-end and Scaled Applications
Bioreactors and Fermenters need to be sterilized absolute secure and reliable for working on high sensitivity levels. They have to comply to recent GMP-guidelines and FDA-standards. The challenge for successful sterile tests is to supply steam and/or cleaning detergents to all parts in media contact for 100 % of their surfaces and over the required time.
The xCUBIO in-situ performs these CIP- (Cleaning in Place) and SIP- (Sterilization in Place) processes fully automatic, reliably safe and reproducible.
xCUBIO in-situ: General
- Reliable and reproducible sterility
- Practically no dead volumes
- Standard systems with 5, 10, 20, 30 or 50 Litres
- All additional sizes customized projects up to 15 m³ operating volume
- Stand-alone bioreactors or integrated installations
- Qualification-ready, validation supported
- Most flexible equipment selection: automation, sensors, gassing
Technical Equipment and Opportunities
- Compact skid installation, mobile, even as twin
- Certified stainless steel vessels
- Up to 10 internal media pumps
- Arbitrary external pumps or other drives
- Most complex gassing regimes with full-grade MFC-control
- Complete inline sensors selection
- Automatic sampling, analysis and result feedback (PAT) with bioPROBE
- Integrated or external steam generators
Bioreactor Automation in xCUBIO in-situ
- 19″-Touch-Display, additional local terminals on demand
- Complete system display in well-arranged presentation
- Intuitive operation with pleasant HMI
- Powerful trend display with analysis tool
- Flexible sequence editor for arbirtrary user-specific processes
- Integration into superior process software via OPC
- Software adaptation to every user demand
- Value-logging and GMP-compliant storage
The basis of xCUBIO enables bbi-biotech to supply qualified turn-key in-situ bioreactor installations for validated production processes after engineering, procurement, mounting and testing trials. We support the compilation of your necessary documentation.