Manual and automated sampling solutions for bioreactors
From sampling valves and aerosol-free manual sampling hardware to automated sterile sampling with bioPROBE – bbi-biotech supports reliable sample withdrawal and sample handling for bioreactors across laboratory, process development and in-situ applications.
- Manual samplers
- Manual sampling valves
- Aerosol-free sampling headpieces
- Automated sterile sampling
- Single- and multi-reactor workflows
- Filtration, cooling and analyzer options
All bbi-biotech sampling solutions can be customized to customer specifications.

Manual sampling hardware or automated sterile sampling?
Bioreactor sampling can be a simple manual routine, a controlled in-situ sampling step or a fully automated sterile workflow. bbi-biotech offers both practical sampling hardware for manual use and configurable bioPROBE systems for automated sample collection and sample handling.
Manual Bioreactor Sampling

The practical route for routine sampling, in-situ reactors and manual sampling hardware.
For many bioreactor processes, manual sampling is still the most direct and efficient route. bbi-biotech provides sampling valves, aerosol-free headpieces and manual samplers for controlled sample withdrawal in laboratory, process development and in-situ bioreactor workflows.
Choose this path when you need reliable sampling hardware, defined standard products or a controlled manual sampling concept – without building a fully automated workflow around the process.
- Sampling valves for in-situ bioreactors
- Headpieces for aerosol-free manual sampling
- Manual samplers and sampling accessories
- Practical shop products and replacement parts
- Technical support for suitable sampling hardware
Automated Sterile Sampling with bioPROBE

The advanced route for defined sampling times, reproducibility and structured sample handling.
When sampling timing, reproducibility and sample handling become critical, bioPROBE automates sterile sample withdrawal from bioreactors of all manufacturers. The same sampling principle supports one reactor or synchronized workflows with up to four reactor lines.
Choose this path when you need defined sampling times, reduced manual intervention or structured sample handling — including filtration, cooling, freezing or analyzer options where configured.
- bioPROBE single for one bioreactor
- bioPROBE quad for up to four reactor lines
- Synchronized sampling across multiple reactors
- orbitSAM, multiSAM and iceBLOCK configurations
- Filtration, cooling and analyzer options
Choose your starting point – From manual sampling hardware to automated sample handling
Most bioreactor samples are still taken manually – and for many workflows, that remains the right approach. Use this guide to choose the right starting point: standard manual products, controlled sampling valves, automated sterile sampling with bioPROBE or advanced sample handling with cooling, filtration or analyzer preparation.
Manual sampling products and parts

For routine sampling workflows and standard products available on request.
Choose this route when you already know the sampling hardware you need and want to request defined products from the bbi-biotech shop, such as manual samplers, sterile filter membranes, sterile sleeves and related sampling accessories for bioreactors.
- Manual samplers for bioreactors
- Sterile filter membranes and holders
- Sterile addition ports and sleeves
- Sampling accessories and connectors
- Standard products available on request
Sampling valves and aerosol-free sampling

For controlled manual sampling from in-situ and SIP-capable bioreactors.
Choose this route when you need intermediate-sterilizable sampling valves, standard valve assemblies, customized connections or containment-oriented sampling concepts with steam lines, sterile sleeves, TC-clamps, membranes and aerosol-free headpieces.
- Intermediate-sterilizable sampling valves
- Standard or customized connections
- Steam line and sterile sleeve concepts
- Aerosol-free sampling headpieces
- Containment sampling configurations
Automated sterile sampling workflows

For defined sampling times, reproducibility and reduced manual work.
Choose this route when manual sampling is still possible, but timing, workload or reproducibility become limiting factors. bioPROBE automates sterile sample withdrawal from all bioreactor brands, from one reactor line to multi-reactor workflows.
- Automated sterile sample withdrawal
- bioPROBE single for one reactor line
- bioPROBE quad for multiple reactor lines
- Synchronized sampling workflows
- Reduced manual sampling effort
Advanced sample handling options

For workflows where the sample needs more than simple collection.
Choose this route when samples need cooling, filtration, freezing, defined storage or preparation for analysis after withdrawal. multiSAM, iceBLOCK and analyzer-related configurations are planned around the process, sample format and downstream workflow.
- multiSAM configurations and extensions
- iceBLOCK temperature handling modules
- Filtration and freezing options available
- Application-based structured sample storage
- Project-specific analyzer preparation
Why bbi-biotech for bioreactor sampling?
Reliable bioreactor sampling is not only about taking liquid out of a vessel. It touches sterility, sample representativeness, fluid-path design, operator handling and what happens to the sample after withdrawal. bbi-biotech designs sampling solutions around these process realities – from manual valves to automated bioPROBE workflows.

Tell us about your sampling workflow
Whether you need manual sampling hardware, an in-situ sampling valve, automated sterile sampling with bioPROBE or advanced sample handling with cooling, filtration or analyzer preparation – we will route your enquiry to the right next step.

I want to discuss my sampling workflow
For early discussions about sampling frequency, manual or automated sampling routes, sterility requirements, sample handling, cooling, filtration, analyzer preparation or technical feasibility.
I need sampling products or a quotation
For defined requests, manual sampling products, sampling valves, headpieces, membranes, manual samplers, bioPROBE configurations or projects where the required options are already reasonably clear.
I need service, spare parts or replacement items
For running systems, replacement parts, sampling valve membranes, sterile sleeves, spare probes, tubing sets, manual sampling accessories, service cases or selected hardware requests.
Direct contact to Berlin head office
+49 (0)30 221 800 10
info@bbi-biotech.com
bbi-biotech GmbH
Landsberger Str. 259
12623 Berlin
