{"id":2438,"date":"2023-08-02T13:48:27","date_gmt":"2023-08-02T11:48:27","guid":{"rendered":"http:\/\/bbi-biotech.com\/?page_id=2438"},"modified":"2026-05-26T01:12:44","modified_gmt":"2026-05-25T23:12:44","slug":"automated-sampling","status":"publish","type":"page","link":"https:\/\/bbi-biotech.com\/en\/bioreactor-sampling\/automated-sampling\/","title":{"rendered":"Automated Sterile Sampling from Bioreactors with bioPROBE"},"content":{"rendered":"\n
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Turn bioreactor sampling into a controlled workflow<\/h2>\n\n\n\n
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Automate sterile sample withdrawal, define sampling routines and connect your bioreactor to structured sample handling – from simple collection to filtration, cooling, freezing and analytics-oriented workflows.<\/p>\n<\/blockquote>\n\n\n\n

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Higher sampling resolution<\/p>\n<\/div><\/div>\n<\/div>\n\n\n\n

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Reduced manual workload<\/p>\n<\/div><\/div>\n<\/div>\n<\/div>\n\n\n\n

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Sterile-by-design withdrawal<\/p>\n<\/div><\/div>\n<\/div>\n\n\n\n

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Configurable sample handling<\/p>\n<\/div><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n

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\"bioPROBE<\/figure>\n<\/div>\n<\/div>\n\n\n\n

Patented sterile sampling technology for glass, stainless-steel, single-use, autoclavable and in-situ bioreactor systems.<\/em><\/p>\n\n\n\n

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Discuss your sampling workflow<\/a><\/div>\n<\/div>\n<\/div>\n\n\n\n
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Explore bioPROBE configurations<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n
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Four reasons to automate bioreactor sampling<\/h2>\n\n\n\n
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Automated sampling becomes valuable when sampling is no longer an occasional manual step, but a repeated process requirement. bioPROBE helps bioprocess teams define when samples are taken, protect how they are withdrawn and control what happens to them after leaving the reactor.<\/p>\n<\/blockquote>\n\n\n\n

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Higher sampling resolution<\/p>\n\n\n\n

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Better process understanding and more reliable development decisions.<\/p>\n\n\n\n

Sparse manual samples can miss relevant process dynamics between two sampling points. bioPROBE enables more frequent, scheduled sample withdrawal, helping teams capture a higher-resolution view of offline parameters during critical process phases.<\/p>\n<\/div>\n\n\n\n

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Reduced manual workload<\/p>\n\n\n\n

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Less routine work and more predictable use of laboratory resources.<\/p>\n\n\n\n

Manual sampling interrupts operators, binds trained staff and becomes difficult during nights, weekends or long cultivations. bioPROBE automates repeated sampling routines, reducing dependency on constant manual intervention at the reactor.<\/p>\n<\/div>\n\n\n\n

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Sterile-by-design <\/p>\n\n\n\n

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Safer sampling workflows for sensitive bioprocess applications.<\/p>\n\n\n\n

Every sampling step must protect the bioreactor and the sample. bioPROBE is designed around sterile sample withdrawal, defined transfer paths and application-specific handling concepts to reduce contamination-related process risks.<\/p>\n<\/div>\n\n\n\n

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Configurable handling<\/p>\n\n\n\n

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A structured path from reactor sampling to usable process information.<\/p>\n\n\n\n

The value of sampling does not end at withdrawal. Depending on configuration, bioPROBE can connect sample collection with filtration, cooled storage, frozen storage or analytics-oriented workflows after the sample leaves the reactor.<\/p>\n<\/div>\n<\/div>\n\n\n\n

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Reveal process dynamics that manual sampling can miss<\/h2>\n\n\n\n
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Manual sampling often provides only a small number of selected data points. That can be enough for basic checks, but it may hide relevant changes between two sampling events. With bioPROBE, samples can be taken more frequently and at defined times. This helps process teams capture a more detailed view of the same bioprocess – especially during fast-changing, critical or poorly understood process phases.<\/p>\n<\/blockquote>\n\n\n

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\"Conceptual<\/figure>\n<\/div>\n\n\n

Automated sterile sampling increases the time resolution of offline process data, helping teams understand what happens between individual manual samples.<\/em><\/p>\n\n\n\n

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When sampling becomes frequent, scheduled or parallel, the real cost is the repeated manual work behind every sample.<\/h2>\n\n\n\n
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Manual sampling starts simple, but every additional sample adds operator time, reactor access, handling and documentation. bioPROBE requires an initial setup, but once the workflow is defined, each further sample can be taken with much lower recurring effort.<\/p>\n<\/blockquote>\n\n\n

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Frequent sampling<\/p>\n\n\n\n

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The more samples a process requires, the more manual sampling turns into repeated routine work.<\/p>\n<\/div>\n\n\n\n

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Defined sampling times<\/p>\n\n\n\n

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Samples may be needed at process-relevant moments, not only when an operator is available.<\/p>\n<\/div>\n\n\n\n

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Night and weekend runs<\/p>\n\n\n\n

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Automated routines can reduce manual sampling pressure out\u00adside normal working hours and un\u00adattended process phases.<\/p>\n<\/div>\n\n\n\n

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Parallel bioreactors<\/p>\n\n\n\n

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Synchronized sampling across several reactor lines becomes difficult to maintain manually over long runs.<\/p>\n<\/div>\n<\/div>\n\n\n\n

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From repeated manual intervention to a controlled sampling workflow<\/h2>\n\n\n\n
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Manual sampling is not only the moment of taking a sample. It includes timing, reactor access, handling, transfer, documentation and follow-up steps – every time a sample is required. With bioPROBE, sampling can become a defined workflow: samples are withdrawn at planned times, transferred through a controlled path and routed into the configured handling steps after leaving the reactor.<\/p>\n<\/blockquote>\n\n\n\n

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Manual sampling<\/h3>\n\n\n
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Operator-dependent timing<\/strong>
Samples are taken when trained staff are available, not always when the process reaches the most relevant phase.<\/p>\n\n\n\n

Few individual data points<\/strong>
Manual routines often limit the number of samples, especially during long runs, nights, weekends or parallel experiments.<\/p>\n\n\n\n

Repeated manual intervention<\/strong>
Every sample requires reactor access, preparation, handling, transfer and documentation as a separate manual task.<\/p>\n\n\n\n

Manual follow-up steps<\/strong>
Collection, filtration, cooling, freezing or transfer to analytics often happen as additional disconnected steps after sampling.<\/p>\n\n\n\n

Higher risk of timing drift<\/strong>
Sampling times can shift between operators, shifts, reactors or campaigns, reducing comparability between runs.<\/p>\n\n\n\n

Difficult parallel coordination<\/strong>
Keeping several reactor lines synchronized manually becomes harder as sampling frequency and process duration increase.<\/p>\n<\/div>\n\n\n\n

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Sampling with bioPROBE<\/h3>\n\n\n
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Defined sampling routines<\/strong>
Samples can be taken according to planned routines, helping teams collect data at process-relevant moments.<\/p>\n\n\n\n

Higher offline data resolution<\/strong>
More frequent sampling can reveal process dynamics that sparse manual samples may miss.<\/p>\n\n\n\n

Automated sterile withdrawal and transfer<\/strong>
Sampling is moved from repeated manual handling to a controlled withdrawal and transfer workflow.<\/p>\n\n\n\n

Configurable sample handling<\/strong>
Samples can be routed into collection, filtration, cooling, freezing or analytics-oriented workflows depending on configuration.<\/p>\n\n\n\n

More repeatable workflows<\/strong>
Defined routines help reduce operator-dependent variation between runs, shifts and repeated campaigns.<\/p>\n\n\n\n

Better synchronization across reactor lines<\/strong>
Parallel sampling workflows can be aligned more consistently across multiple bioreactors.<\/p>\n<\/div>\n<\/div>\n\n\n\n

This is the central shift: bioPROBE does not only automate the act of taking a sample – it helps define the complete sampling workflow around the process.<\/p>\n\n\n\n

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A sterile sampling platform for bioprocesses where timing, reproducibility and sample handling matter<\/h2>\n\n\n\n
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bioPROBE is an automated sterile sampling technology for bioreactors. It combines a dedicated sampling probe, controlled sample withdrawal and configurable sample handling for workflows where manual sampling becomes too limited or too inconsistent.<\/p>\n<\/blockquote>\n\n\n\n

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bioPROBE is designed to withdraw samples from a defined position in the bioreactor and transfer them through a controlled path into the selected sample-handling setup.<\/p>\n\n\n\n

Depending on configuration, this can mean direct collection, filtration after withdrawal, cooled or frozen storage, or preparation for analytics-oriented workflows.<\/p>\n\n\n\n

It becomes especially valuable when samples are needed frequently, at defined process times, across parallel reactors or in workflows where sterility, reproducibility and downstream handling are critical.<\/p>\n<\/div>\n\n\n\n

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bioPROBE is not simply an autosampler. It is the sampling interface between the bioreactor and a defined sample-handling workflow.<\/em><\/p>\n\n\n\n

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One sampling technology, configured for simple collection or advanced parallel sample handling<\/h2>\n\n\n\n
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bioPROBE can be configured as a straightforward single-reactor sampling solution or as an advanced platform for up to four reactor lines. The right path depends on reactor count, sampling frequency and what needs to happen to the sample after withdrawal.<\/p>\n<\/blockquote>\n\n\n\n

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bioPROBE single + orbitSAM – For one bioreactor or one sampling line<\/p>\n\n\n\n

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bioPROBE single with orbitSAM is the practical entry into automated sterile sampling. It is designed for laboratories that need defined sampling times, reduced manual intervention and straightforward automated sample collection from one reactor line.<\/p>\n\n\n\n

Best for<\/strong><\/p>\n\n\n\n