{"id":105,"date":"2023-04-23T23:52:01","date_gmt":"2023-04-23T21:52:01","guid":{"rendered":"http:\/\/bbi-biotech.com\/bioreactors-fermenters\/in-situ-bioreactors\/"},"modified":"2023-08-23T11:27:42","modified_gmt":"2023-08-23T09:27:42","slug":"in-situ-bioreactors","status":"publish","type":"page","link":"https:\/\/bbi-biotech.com\/en\/bioreactors-fermenters\/in-situ-bioreactors\/","title":{"rendered":"xCUBIO in-situ"},"content":{"rendered":"\n<h2 class=\"wp-block-heading has-text-align-left\"><strong><mark style=\"background-color:rgba(0, 0, 0, 0);color:#007d44\" class=\"has-inline-color\">SIP\/CIP-Technology for High-end and Scaled Applications<\/mark><\/strong><\/h2>\n\n\n\n<p>Bioreactors and Fermenters need to be sterilized absolute secure and reliable for working on high sensitivity levels. They have to comply to recent <strong>GMP-guidelines<\/strong> and <strong>FDA-standards<\/strong>. The challenge for successful sterile tests is to supply steam and\/or cleaning detergents to all parts in media contact for 100 % of their surfaces and over the required time.<\/p>\n\n\n\n<p>The <strong>xCUBIO in-situ<\/strong> performs these CIP- (Cleaning in Place) and SIP- (Sterilization in Place) processes fully automatic, reliably safe and reproducible.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong><mark style=\"background-color:rgba(0, 0, 0, 0);color:#007d44\" class=\"has-inline-color\">xCUBIO in-situ: General<\/mark><\/strong><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Reliable and reproducible sterility<\/li>\n\n\n\n<li>Practically no dead volumes<\/li>\n\n\n\n<li>Standard systems with 5, 10, 20, 30 or 50 Litres<\/li>\n\n\n\n<li>All additional sizes customized projects up to 15 m\u00b3 operating volume<\/li>\n\n\n\n<li>Stand-alone bioreactors or integrated installations<\/li>\n\n\n\n<li>Qualification-ready, validation supported<\/li>\n\n\n\n<li>Most flexible equipment selection: automation, sensors, gassing<\/li>\n<\/ul>\n\n\n\n<p><\/p>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img decoding=\"async\" data-src=\"http:\/\/bbi-biotech.com\/wp-content\/uploads\/2023\/07\/xCUBIO-in-situ-bioreactor-by-bbi-biotech-185x300-1.jpg\" alt=\"\" class=\"wp-image-1335 lazyload\" style=\"--smush-placeholder-width: 235px; --smush-placeholder-aspect-ratio: 235\/381;width:235px;height:381px\" width=\"235\" height=\"381\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" \/><figcaption class=\"wp-element-caption\"><strong><mark style=\"background-color:rgba(0, 0, 0, 0);color:#007d44\" class=\"has-inline-color\">xCUBIO in-situ: SIP\/CIP sterilisable bioreactor 150 Litres<\/mark><\/strong><\/figcaption><\/figure>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p><strong><mark style=\"background-color:rgba(0, 0, 0, 0);color:#007d44\" class=\"has-inline-color\">Technical Equipment and Opportunities<\/mark><\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Compact skid installation, mobile, even as twin<\/li>\n\n\n\n<li>Certified stainless steel vessels<\/li>\n\n\n\n<li>Up to 10 internal media pumps<\/li>\n\n\n\n<li>Arbitrary external pumps or other drives<\/li>\n\n\n\n<li>Most complex gassing regimes with full-grade MFC-control<\/li>\n\n\n\n<li>Complete inline sensors selection<\/li>\n\n\n\n<li>Automatic sampling, analysis and result feedback (PAT) with <a rel=\"noreferrer noopener\" href=\"https:\/\/bbi-biotech.com\/en\/produkte\/probenahme-probenhandling\/probenahme-autosampler\/\" target=\"_blank\">bioPROBE<\/a><\/li>\n\n\n\n<li>Integrated or external steam generators<\/li>\n<\/ul>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img decoding=\"async\" data-src=\"http:\/\/bbi-biotech.com\/wp-content\/uploads\/2023\/07\/xCUBIO-in-situ-bioreactor-30-by-bbi-biotech.jpg\" alt=\"\" class=\"wp-image-1337 lazyload\" style=\"--smush-placeholder-width: 240px; --smush-placeholder-aspect-ratio: 240\/390;width:240px;height:390px\" width=\"240\" height=\"390\" data-srcset=\"https:\/\/bbi-biotech.com\/wp-content\/uploads\/2023\/07\/xCUBIO-in-situ-bioreactor-30-by-bbi-biotech.jpg 308w, https:\/\/bbi-biotech.com\/wp-content\/uploads\/2023\/07\/xCUBIO-in-situ-bioreactor-30-by-bbi-biotech-185x300.jpg 185w\" data-sizes=\"(max-width: 240px) 100vw, 240px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" \/><figcaption class=\"wp-element-caption\"><strong><mark style=\"background-color:rgba(0, 0, 0, 0);color:#007d44\" class=\"has-inline-color\">xCUBIO in-situ: SIP\/CIP sterilisable bioreactor 30 Litres<\/mark><\/strong><\/figcaption><\/figure>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p><strong><mark style=\"background-color:rgba(0, 0, 0, 0);color:#007d44\" class=\"has-inline-color\">Bioreactor Automation in xCUBIO in-situ<\/mark><\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>19\u2033-Touch-Display, additional local terminals on demand<\/li>\n\n\n\n<li>Complete system display in well-arranged presentation<\/li>\n\n\n\n<li>Intuitive operation with pleasant HMI<\/li>\n\n\n\n<li>Powerful trend display with analysis tool<\/li>\n\n\n\n<li>Flexible sequence editor for arbirtrary user-specific processes<\/li>\n\n\n\n<li>Integration into superior process software via OPC<\/li>\n\n\n\n<li>Software adaptation to every user demand<\/li>\n\n\n\n<li>Value-logging and GMP-compliant storage<\/li>\n<\/ul>\n<\/div>\n<\/div>\n\n\n\n<p>The basis of xCUBIO enables <strong>bbi-biotech<\/strong> to supply qualified turn-key in-situ bioreactor installations for validated production processes after engineering, procurement, mounting and testing trials. We support the compilation of your necessary documentation.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>SIP\/CIP-Technology for High-end and Scaled Applications Bioreactors and Fermenters need to be sterilized absolute secure and reliable for working on high sensitivity levels. They have to comply to recent GMP-guidelines and FDA-standards. The challenge for successful sterile tests is to supply steam and\/or cleaning detergents to all parts in media contact for 100 % of [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":102,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"template-fullwidth.php","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-105","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/bbi-biotech.com\/en\/wp-json\/wp\/v2\/pages\/105","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bbi-biotech.com\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/bbi-biotech.com\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/bbi-biotech.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/bbi-biotech.com\/en\/wp-json\/wp\/v2\/comments?post=105"}],"version-history":[{"count":0,"href":"https:\/\/bbi-biotech.com\/en\/wp-json\/wp\/v2\/pages\/105\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/bbi-biotech.com\/en\/wp-json\/wp\/v2\/pages\/102"}],"wp:attachment":[{"href":"https:\/\/bbi-biotech.com\/en\/wp-json\/wp\/v2\/media?parent=105"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}